UPDATE: All lanes of I-65S were reopened around 2:50 a.m.
A portion of Interstate 65 South was closed near Sellersburg after a semi fire Tuesday night.
The accident happened around 10:30 p.m. Indiana State Police said traffic near the 10-mile marker was diverted for several hours.
The right two lanes were reopened before midnight, but the left lane did not reopen until almost 3 a.m.
Police did not say if anyone was hurt in the crash.