LOUISVILLE, Ky. (WHAS 11)-- A deadly crash involving a semi-truck has shut down parts of I-65.

The crash happened around 12:30 a.m. on I-65 Southbound in Seymour, Indiana just north of Exit 50 in Jackson Co.

Indiana State Police said a Louisville, Ky. man was killed in the crash. Sixty-five-year-old James Foster was driving south on I-65 in a 2014 Freightliner Truck, which was pulling a box trailer. He was in the right lane of I-65 approaching exit 50 and for an unknown reason, he failed to change lanes and hit an Indiana Department of Transportation 2008 International dump truck. That truck was not occupied but was intended to provide lane blockage for crews that were conducting repairs to an I-65 overpass over US 50. The INDOT vehicle did have red and yellow lights on, as well as a flashing arrow board, at the time of the crash.

Foster lost control after impact, his Freightliner overturned and came to rest partially on the roadway. He was fatally injured and pronounced dead at the scene. No one else was injured.

Traffic on I-65 was impacted for six hours as crews worked to clear the crash.

Foster was hauling 35,000 pounds of frozen food. Crews had to unload the food and upright the Freightliner.