LOUISVILLE (WHAS11) -- Indiana State Police are investigating a head-on crash on State Road 111 this morning, about half a mile north of the Horseshoe casino. This roadway is known for its share of accidents.

Indiana State Police sa46-year-old Louisville resident Dennis Masticola was driving northbound when he crossed the center line. He crashed into a Pickup Truck being driven by 46 year old Eric Herthel from Elizabeth, Indiana.

Police tell us both drivers had to be extricated from their vehicles and were taken to University Hospital with serious injuries. Police are still investigating what happened and why.

This is a developing story.